Biography
Currently, my work focuses on the effect of fluids flow in defining the structure and biological function of the biopolymer brushes found on the surface of the blood vessel wall. This structure is just one example of the cell surface expression of the large polymer hyaluronan that the cell uses to define the properties of cell-fluid and cell tissue interfaces.
Education Background
Physics Ph.D. - University of Oxford
Optoelectronics and Laser Engineering M.S. - Heriot-Watt University
Experience
Assistant Professor Department of Physics, 今日吃瓜黑料, 2013-present
Postdoctoral Fellow Department of Physics, Georgia Institute of Technology, 2008-2013
Courses Taught
- PH141 - Physics for Life Sciences I鈥
- PH142 - Physics for Life Sciences II鈥
- PH323 - Optics 鈥
- PH341 - Solid State Physics鈥
- PH320 - Physical Models of Living Systems
- PH426 - Intro to Biophysics鈥
- PH451 - Statistical Mechanics I鈥
Research Interests
- Cell physics
- Soft materials
- Tissue engineering
- Advanced microscopy
Awards
- National Science Foundation CAREER Award 2019鈥
- 今日吃瓜黑料 Ignite Fellowship, 2018鈥
- Outstanding New Teacher Award 今日吃瓜黑料 2017鈥
Publications
- Driving Complex Flow Waveforms with a Linear Voice Coil Actuator鈥 D. C. Young, J. M. Brehm, and J. Scrimgeour 鈥婤iomicrofluidics, 13, 034101 (2019)鈥
- Adhesion and Mechanical Properties of P-selectin PSGL-1 Bonds 鈥婤. Farzi, D. C. Young, J. Scrimgeour, and C. Cetincaya鈥 Colloids and Surfaces B: Biointerfaces, 173, 529 (2019)鈥
- Adhesion and Stiffness of Biotin-Superavidin Bonds鈥 B. Farzi, J. Scrimgeour, and C. Cetincaya 鈥婥olloids and Surfaces B: Biointerfaces, 171, 308 (2018)鈥
- Optimizing Likelihood Models for Particle Trajectory Segmentation in Multi-State Systems 鈥婦. C. Young and J. Scrimgeour鈥 Physical biology, 15(6), 066003 (2018)鈥
- Incorporation of Soft Shaped Hydrogel Sheets into Microfluidic Systems using a Simple Adhesion Masking Process鈥 D. C. Young, I. G. Newsome and J. Scrimgeour鈥 Appl. Phys. Lett. 111, 263705 (2017)鈥
- Single-Molecule Imaging of Proteoglycans in the Pericellular Matrix 鈥婮. Scrimgeour, L. T. McLane, P. S. Chang, and J. E. Curtis鈥 Biophys. J. 113, 2316 (2017)鈥
- Cell Surface Access Is Modulated by Tethered Bottlebrush Proteoglycans鈥 P. S. Chang, L. T. McLane, R. Fogg, J. Scrimgeour, J. S. Temenoff, A Granqvist, and J. E. Curtis 鈥婤iophys. J. 110, 2739 (2016)鈥
- A Fast Weighted Centroid Algorithm for Single Particle Localization Near the Information Limit 鈥婮. Fish and J. Scrimgeour 鈥婣ppl. Opt. 54, 6140 (2015)鈥
- Speed Dependence of Thermochemical Nanolithography for Gray-Scale Patterning鈥 K. M. Carroll, M. Desai, A. J. Giordano, J. Scrimgeour, W. P. King, E. Riedo, and J. E. Curtis鈥 ChemPhysChem, 15, 2530 (2014)鈥
- K. M. Carroll, A. J. Giordano, D. Wang, V. K. Kodali, J. Scrimgeour, W. P. King, S. R. Marder, E. Riedo, and J. E. Curtis, 鈥淔abricating Nanoscale Chemical Gradients with ThermoChemical NanoLithography鈥, Langmuir, 29, 2013, 8675鈥8682.
- D. W. Dumbauld, T. T. Lee, A. Singh, J. Scrimgeour, C. A. Gersbach, E. A. Zamir, J. Fu, C. S. Chen, J. E. Curtis, S. W. Craig, A. J. Garc铆a. 鈥淗ow Vinculin Regulates Force Transmission鈥, PNAS, May, 2013; doi: 10.1073/pnas.1216209110.
- L. T. McLane, P. Chang, A. Granqvist, H. Boehm, A. Kramer, J. Scrimgeour, J. E. Curtis, 鈥淪patial Organization and Mechanical Properties of the Pericellular Matrix on Chondrocytes鈥, Biophysical Journal, 104, 2013, 986-996,
- J. Scrimgeour, A. San Miguel, J. E. Curtis, S. H. Behrens. 鈥淎 Generalized Approach for Measuring Microcapsule Permeability with Fluorescence Recovery After Photobleaching鈥, Journal of Materials Science, 48, 2013, 2215-2223.
- J. Scrimgeour and J. E. Curtis. 鈥淎berration Correction in Wide-field Fluorescence Microscopy by Segmented-Pupil Image Interferometry鈥, Optics Express 20(13), 14534 (2012). Selected for The Virtual Journal for Biomedical Optics 7(8) (2012).
- J. Scrimgeour, J,-K Cho, V. Breedveld and J. E. Curtis. 鈥淢icrofluidic dialysis cell for characterization of macromolecule interactions鈥, Soft Matter 7, 4762 (2011).
- V. Kodali, J. Scrimgeour, S. Kim, J. H. Hankinson, W. A. de Heer, C. Berger, and J. E. Curtis. 鈥淣on-Perturbative Chemical Modification of Graphene for Protein Micropatterning鈥, Langmuir 27, 863 (2011).
- A. San Miguel, J Scrimgeour, J. E. Curtis and S. H. Behrens, 鈥淪mart Colloidosomes with Tunable Permeability and Dissolution Trigger鈥, Soft Matter 6, 3163 (2010).
- J. Scrimgeour, V. Kodali, D. Kovari, and J. E. Curtis. 鈥淧hotobleaching- Activated Chemical Micropatterning on Self-Assembled Monolayers鈥, J. Phys.: Condens. Matter 22, 194103 (2010).
- E. Eriksson, K. Sott, F. Lundqvist, M. Sveningsson, J. Scrimgeour, D. Hanstorp, M. Goks枚r and A. Gran茅li. 鈥淎 microfluidic device for reversible environmental changes around single cells using optical tweezers for cell selection and positioning鈥, Lab on a Chip 10, 610 (2010).
- E. Eriksson, D. Engstrom, J. Scrimgeour and M. Goks枚r. 鈥淎utomated focusing of nuclei for timelapse experiments on single cells using holographic optical tweezers鈥, Optics Express 17, 5585 (2009). Selected for The Virtual Journal for Biomedical Optics 4(5) (2009).
- U. Mirsaidov, J. Scrimgeour, W. Timp, K. Beck, M. Mir, P. Matsudaira, and G. Timp. 鈥淟ive Cell Lithography: Using optical tweezers to create synthetic tissue鈥, Lab on a Chip 8, 2174 (2008). Selected for the Virtual Journal Chemical Biology Research Articles,1(2009).
- A. H枚gele, S. Seidl, M. Kroner, K. Karrai, C. Schulhauser, O. Sqalli, J. Scrimgeour, and R. J. Warburton. 鈥淔iber-based confocal microscope for cryogenic spectroscopy鈥, Rev. Sci. Instrum. 79, 023709 (2008).
- E. Eriksson, J. Scrimgeour, A. Gran茅li, K. Ramser, R. Wellander, J. Enger, D. Hanstorp and M. Goks枚r. 鈥淥ptical Manipulation and Microfluidics for Studies of Single Cell Dynamics鈥, J. Opt. A: Pure Appl. Opt. 9, S113 (2007).
- J. Scrimgeour, D. N. Sharp, C. F. Blanford, O. M. Roche, R. G. Denning and A. J. Turberfield, 鈥淭hree-Dimensional Optical Lithography for Photonic Microstructures鈥, Advanced Materials 18(12) 1557 (2006).
- J. S. King, E. Graugnard, O. M. Roche, D. N. Sharp, J. Scrimgeour, R. G. Denning, A. J. Turberfield, and C. J. Summers, 鈥淚nfiltration and Inversion of Holographically-Defined Polymer Photonic Crystal Templates by Atomic Layer Deposition鈥, Advanced Materials 18(12) 1561 (2006).
- K. H. Lee, A. M. Green, R. A. Taylor, D. N. Sharp, J. Scrimgeour, O. M. Roche, J. H. Na, A. F. Jarjour, A. J. Turberfield, F. S. F. Brossard, D. A. Williams and G. A. D. Briggs. 鈥淩egistration of single quantum dots using cryogenic laser photolithography鈥, Applied Physics Letters 88, 193106 (2006).
Book Chapters
- G. Timp, U. Mirsaidov, W. Timp, J. Shim, D. Wang, V. Dimitrov, J. Scrimgeour, C. Lin, J, Comer, A. H. Ho, X. Zou, A. Aksimentiev, and K. Shulten, 鈥淭hird Generation DNA Sequencing with a Nanopore.鈥 Nanopores: Sensing and Fundamental Biological Interactions (2011).
- J. Scrimgeour, E. Eriksson and M. Goks枚r, 鈥淟aser Surgery and optical trapping in a laser scanning microscope鈥, Methods in Cell Biology: Laser manipulation of Cells and Tissues. (2007).